My research is in the technical development and applications of Functional Magnetic Resonance Imaging (fMRI) methods to understand human brain function. I am involved in the development of a noninvasive method to measure cerebral blood flow — arterial spin labeling (ASL) perfusion MRI. We are pursuing several directions including high magnetic field, parallel imaging, artifact reduction, simultaneous oxygenation imaging, pediatric applications and to use ASL as a new contrast for functional neuroimaging studies. We are starting to use perfusion fMRI for cognitive neuroscience studies, including psychological stress, sustained attention, drug addiction, learning and sleep. I am trying to support and promote the use of perfusion fMRI in the functional neuroimaging community by disseminating the ASL sequences through our website at www.cfn.upenn.edu/perfusion I am also collaborating with researchers in nuclear medicine (PET), optical imaging and electrophysiology (EEG) to combine fMRI with these methods.

1989-1993 B.S. Fu Dan University, Shanghai, China (Biophysics)

1993-1998 Ph.D. University of Science and Technology of China, Beijing, China (Biophysics)

1. J. Wang, D.J. Licht (2006) Pediatric perfusion MRI with arterial spin labeling Neuroimaging Clinics of North America 16: 149-167

2. J. Wang, H. Rao, G.S. Wetmore, P.M. Furlan, M. Korczykowski, D.F. Dinges, J.A. Detre (2005) Perfusion fMRI reveals cerebral blood flow pattern under psychological stress. Proceedings of the National Academy of Sciences of U.S.A. 102:17804-17809.

3.  J.Wang, Z. Wang, G.K. Aguirre, J.A. Detre (2005) To smooth or not to smooth? – ROC analysis of perfusion fMRI data. Magn. Reson. Imag. 23: 75-81

4.  J. Wang, Y. Zhang, R.L. Wolf, A.C. Roc, D.C. Alsop and J.A. Detre (2005) Amplitude modulated continuous arterial spin labeling perfusion MRI with single coil at 3.0 Tesla. Radiology 235:218-228

5.  J. Wang, D.J. Licht, G.H. Jahng, C.S. Liu, J.T. Rabin, J. Haselgrove, R.A. Zimmerman and J.A. Detre (2003) Pediatric perfusion imaging using pulsed arterial spin labeling. J. Magn. Reson. Img. 18(4):404-413.

6.  J. Wang, G.K. Aguirre, D.Y. Kimberg, J.A. Detre (2003) Empirical analyses of null-hypothesis perfusion fMRI data at 1.5 and 4.0 Tesla. Neuroimage. 19(4):1449-1462.

7.  J. Wang, D.C. Alsop, H.K. Song, J.A. Maldijian, K. Tang, A.E. Salvucci, J.A. Detre. (2003) Transit time imaging with flow encoding arterial spin tagging (FEAST). Magn. Reson. Med. 50(3):599-607.

8.  J. Wang, G.K. Aguirre, D.Y. Kimberg, A.C. Roc, L. Li, J.A. Detre (2003) Arterial spin labeling perfusion fMRI with very low task frequency. Magn. Reson. Med. 49: 796-802.

9.   J. Wang, D.C. Alsop, L. Li, J. Listerud, J.B. Gonzalez-At, M.D. Schnall and J.A. Detre (2002) Comparison of Quantitative Perfusion Imaging using Arterial Spin Labeling at 1.5 and 4.0 Tesla.  Magn. Reson. Med. 48:242-254.

10.  J. Wang, T. Zhou, M. Qiu, A. Du, K. Cai, Z. Wang, C. Zhou, M. Meng, Y. Zhuo, S. Fan and L. Chen. (1999) Relationship between Ventral Stream for Object Vision and Dorsal Stream for Spatial Vision: an fMRI+ERP Study. Human Brain Mapping 8(4): 170-181.

11.  J. Wang, Y. Jin, F. Xiao, S. Fan and L. Chen. (1999) Attention-Sensitive Event-Related Potentials Elicited by Kinetic Forms. Clin. Neurophysio. 110: 329-341.

12.  J. Wang, M. Korczykowski, H. Rao, Y. Fan, J. Pluta, R.C. Gur, B. McEwen, J.A. Detre (2007) Gender differences in Neural Response to Psychological Stress Social Cognitive & Affective Neuroscience (In press)

13.  J. Wang, M.A. Fernandez-Seara, S. Wang, K.S. St Lawrence(2007) When perfusion meets diffusion: in vivo measurement of water permeability in human brain J Cereb Blood Flow Metab 27(4): 839-849.

14.  J. Wang, D.J. Licht(2006) Pediatric perfusion MRI with arterial spin labeling Neuroimaging Clinics of North America 16: 149-167.

Book Chapter:

1. J. Wang, J.A. Detre. Arterial Spin Labeling Perfusion MRI in Stroke. In Clinical MR Neuroimaging, Eds.     J.H. Gillard, A.D. Waldman and P. Barker, Cambridge University Press, Cambridge. P207-222