Perfusion fMRI

Perfusion fMRI may be used to obtain a non-invasive, quantified measure of cereberal blood flow. The properties of the perfusion signal make it well suited to the study of slow changes in neural activity. We are using perfusion fMRI to study the changes in neural activity that accompany perceptual learning, such as being able to classify a face as belonging to one group or another.

Relevant Articles

• GK Aguirre, JA Detre, E Zarahn, D C Alsop. (2002). Experimental design and the relative sensitivity of BOLD and perfusion fMRI. NeuroImage, 15, 488-500.
• J Wang, GK Aguirre, DY Kimberg, JA Detre. (2003). Empirical Analyses of Null-Hypothesis Perfusion fMRI Data at 1.5 and 4T. NeuroImage, 19, 1449-62.
• J Wang, GK Aguirre, DY Kimberg, AC Roc, L Li, JA Detre. (2003). Arterial Spin Labeling Perfusion fMRI with Very Low Task Frequency. Magn Reson Med, 49, 796-802.
• J Wang, Z Wang, GK Aguirre, JA Detre. (2005). To smooth or not to smooth? ROC analysis of perfusion fMRI data. Magn Reson Imaging, 23, 75-81.
• I Olson, H Rao, K Sledge Moore, J Wang, J Detre, GK Aguirre (2006). Using Perfusion fMRI to Measure Continuous Changes in Neural Activity with Learning. Brain and Cognition, 60, 262-71.

A review of the approach

• GK Aguirre, JA Detre, J Wang. (2005). Perfusion fMRI for functional neuroimaging. Int Rev Neurobiol, 66, 213-36. :: View Paper - PDF

More Information

For more information about this and other projects visit the CfN Perfusion fMRI website