Lab Publications

Face and Object Perception

DM Drucker, WT Kerr, GK Aguirre. (2009) Distinguishing conjoint and independent neural tuning for stimulus features with fMRI adaptation. Journal of Neurophysiology. June;101(6):3310-24
1. [ Link to supplementary materials ]
2. [ Link to Faculty of 1000 evaluation ]
3. [ Cached version of F1000 review ]
4. [ Example data set ]
DM Drucker, GK Aguirre. (2009) Different spatial scales of shape similarity representation in lateral and ventral LOC. Cerebral Cortex, 19(10), 2269-2280.
A Chatterjee, A Thomas, S Smith, GK Aguirre. (2009) The Neural Response to Facial Beauty. Neuropsychology. 23(2), 135-43.
A Harris, GK Aguirre. (2008) The Effects of Parts, Wholes, and Familiarity on Face-Selective Responses in MEG. Journal of Vision, 8(10), 1-12.
AL Thomas, K Lawler, IR Olson, GK Aguirre. (2008) The Philadelphia Face Perception Battery. Archives of Clinical Neuropsychology, 23(2), 175-187.
A Harris, GK Aguirre. (2008) The Representation of Parts and Wholes in Face-Selective Cortex. Journal of Cognitive Neuroscience, 20(5), 863-78.
AM Harris, GK Aguirre. (2007) Toward a Neurofunctional Definition of “Face-Blindness”. Scientific American Mind Matters. Ed: David Dobbs.
AM Harris, GK Aguirre. (2007) Prosopagnosia. Current Biology, 17, 7-8.
GK Aguirre (2007) Continuous carry-over designs for fMRI. Neuroimage, 35, 1480-1494.
RA Epstein, JS Higgins, W Parker, GK Aguirre, S Cooperman (2006) Cortical correlates of face and scene inversion: a comparison. Neuropsychologia, 44, 1145-58.
TA Polk, M Stallcup, GK Aguirre, DC Alsop, M D'Esposito, JA Detre,MJ Farah. (2002) Neural specialization for letter recognition. Journal of Cognitive Neuroscience, 14, 145-159.
GK Aguirre. (2001) Turning the dial on object perception. Neuron, 29, 317-319.
GK Aguirre, R Singh, M D'Esposito. (1999) Stimulus inversion and the responses of face and object-sensitive cortical areas. Neuroreport, 10, 189-194.
MJ Farah, GK Aguirre. (1999) Imaging visual recognition: PET and fMRI studies of the functional anatomy of human visual recognition. Trends in Cognitive Sciences, 3, 179-186.
GK Aguirre. (1999) Face recognition turned upside-down. Neuron, 22, 5-6.
GK Aguirre, MJ Farah. (1998) Human visual object recognition: what have we learned from neuroimaging? Psychobiology, 26, 322-332.
GK Aguirre, E Zarahn, M D'Esposito. (1998) An area within human ventral cortex sensitive to "building" stimuli: evidence and implications. Neuron, 21, 373-383.
M D'Esposito, JA Detre, GK Aguirre, M Stallcup, DC Alsop, LJ Tippet, MJ Farah. (1997) A functional MRI study of mental image generation. Neuropsychologia, 35, 725-730.

Recovery of Visual Function

PD Radoeva, S Prasad, DH Brainard, GK Aguirre. (2008). Neural activity within area V1 reflects unconscious visual performance in a case of Blindsight. Journal of Cognitive Neuroscience, 20(11), 1927-1939.
GK Aguirre, MA Komáromy, AV Cideciyan, DH Brainard, TS Aleman, AJ Roman, BB Avants, JC Gee, M Korczykowski, WW Hauswirth, GM Acland, GD Aguirre, SG Jacobson. (2007, Jun). Visual Cortex Intact and Responsive Despite Early Retinal Blindness from RPE65 Mutation. PLOS-Medicine, 4(6), e230.
AV Cideciyan, TS Aleman, SG Jacobson, H Khanna, A Sumaroka, GK Aguirre, SB Schwartz, EA Windsor, S He, B Chang, EM Stone, A Swaroop. (2007, Nov). Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis. Hum Mutat, 28(11), 1074-83.

Functional MRI Methodology and Interpretation

L Yan, Y Zhou, Y Ye, SX Xie, J An, GK Aguirre, J Wang (2009). Physiological origin of low-frequency drift in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Magnetic Resonance in Medicine. Apr;61(4):819-27.
DM Drucker, WT Kerr, GK Aguirre. (2009). Distinguishing conjoint and independent neural tuning for stimulus features with fMRI adaptation. Journal of Neurophysiology. June;101(6):3310-24 [ Link to supplementary materials ] [ Link to Faculty of 1000 evaluation ]
GK Aguirre. (2008, Sept 12). The Political Brain. Cerebrum.
M Bedny, GK Aguirre, SL Thompson-Schill. (2007) Item analysis in functional magnetic resonance imaging. Neuroimage, 35, 1093-1102.
GK Aguirre (2007) Continuous carry-over designs for fMRI. Neuroimage, 35, 1480-1494.
GK Aguirre. (2006). Interpretation of clinical functional neuroimaging studies. In: D'Esposito, M. (Ed.), Functional MRI: Applications in Clinical Neurology Parthenon Publishing, New York.
GK Aguirre. (2006). Experimental Design and Data Analysis for fMRI. In F. Mohamed & S. H. Faro (Eds.), Functional MRI:Basic Principles and Clinical Applications. Springer-Verlag, New York.
J Wang, Z Wang, GK Aguirre, JA Detre. (2005). To smooth or not to smooth? ROC analysis of perfusion fMRI data. Magn Reson Imaging, 23, 75-81.
GK Aguirre. (2003). Functional imaging in behavioral neurology and cognitive neuropsychology. In T. E. Feinberg & M. J. Farah (Eds.), Behavioral Neurology and Cognitive Neuropsychology. New York: McGraw Hill.
GK Aguirre, JA Detre, E Zarahn, D C Alsop. (2002). Experimental design and the relative sensitivity of BOLD and perfusion fMRI. NeuroImage, 15, 488-500.
GK Aguirre, M D'Esposito. (1999). Experimental Design for Brain fMRI. In C. T. W. Moonen & P. A. Bandettini (Eds.), Functional MRI (pp. 369-380). Berlin: Springer Verlag.
M D'Esposito, E Zarahn, GK Aguirre. (1999). Event-related functional MRI: Implications for cognitive psychology. Psychological Bulletin, 125.
M D'Esposito, E Zarahn, GK Aguirre, B Rypma. (1999). The effect of normal aging on coupling of neural activity to the BOLD hemodynamic response. NeuroImage, 10, 6-14.
GK Aguirre, E Zarahn, M D'Esposito. (1998). A critique of the use of the Kolmogorov-Smirnov (KS) statistic for the analysis of BOLD fMRI data. Magnetic Resonance in Medicine, 39, 500-505.
GK Aguirre, E Zarahn, M D'Esposito. (1998). The inferential impact of global signal covariates in functional neuroimaging analyses. NeuroImage, 8, 302-306.
GK Aguirre, E Zarahn, M D'Esposito. (1998). The variability of human BOLD hemodynamic responses. NeuroImage, 8, 360-369.
E Zarahn, GK Aguirre, M D'Esposito. (1997). A trial-based experimental design for fMRI. Neuroimage, 6, 122-138.
M D'Esposito, E Zarahn, GK Aguirre, RK Shin, P Auerbach, JA Detre. (1997). The effect of pacing of experimental stimuli on observed functional MRI activity. Neuroimage, 6, 113-121.
E Zarahn, GK Aguirre, M D'Esposito. (1997). Empirical analyses of BOLD fMRI statistics. I. Spatially unsmoothed data collected under null-hypothesis conditions. Neuroimage, 5, 179-197.
GK Aguirre, E Zarahn, M D'Esposito. (1997). Empirical analyses of BOLD fMRI statistics. II. Spatially smoothed data collected under null-hypothesis and experimental conditions. Neuroimage, 5, 199-212.

Perfusion fMRI

Z Wang, GK Aguirre, H Rao, J Wang, MA Fernández-Seara, AR Childress, JA Detre. (2007). Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx. Magn Reson Imaging, 26(2), 261-269.
I Olson, H Rao, K Sledge Moore, J Wang, J Detre, GK Aguirre (2006). Using Perfusion fMRI to Measure Continuous Changes in Neural Activity with Learning. Brain and Cognition, 60, 262-71.
GK Aguirre, JA Detre, J Wang. (2005). Perfusion fMRI for functional neuroimaging. Int Rev Neurobiol, 66, 213-36. Download pdf preprint
J Wang, GK Aguirre, DY Kimberg, JA Detre. (2003). Empirical Analyses of Null-Hypothesis Perfusion fMRI Data at 1.5 and 4T. NeuroImage, 19, 1449-62.
J Wang, GK Aguirre, DY Kimberg, AC Roc, L Li, JA Detre. (2003). Arterial Spin Labeling Perfusion fMRI with Very Low Task Frequency. Magn Reson Med, 49, 796-802.
GK Aguirre, JA Detre, E Zarahn, D C Alsop. (2002). Experimental design and the relative sensitivity of BOLD and perfusion fMRI. NeuroImage, 15, 488-500.

Topographical Orientation

GK Aguirre. (2002). Topographical Disorientation. In M D’Esposito (Ed.) Neurological Foundations of Cognitive Neuroscience. Boston: MIT Press.
GK Aguirre, M D'Esposito. (1999). Topographical disorientation: a synthesis and taxonomy. Brain, 122, 1613-1628.
GK Aguirre, E Zarahn, M D'Esposito. (1998). An area within human ventral cortex sensitive to "building" stimuli: evidence and implications. Neuron, 21, 373-383.
GK Aguirre, M D'Esposito. (1997). Environmental knowledge is subserved by separable dorsal/ventral neural areas. Journal of Neuroscience, 17, 2512-2518.
GK Aguirre, JA Detre, DC Alsop, M D'Esposito. (1996). The parahippocampus subserves topographical learning in man. Cerebral Cortex, 6, 823-829.
- View PDF with Color Figures
GK Aguirre, E Zarahn, M D'Esposito. (1998). Neural components of topographical representation. PNAS USA, 95, 839-846.

Learning and Memory

I Olson, H Rao, K Sledge Moore, J Wang, J Detre, GK Aguirre (2006). Using Perfusion fMRI to Measure Continuous Changes in Neural Activity with Learning. Brain and Cognition, 60, 262-71.
AP Jha, SA Fabian, GK Aguirre. (2004). The role of prefrontal cortex in resolving distractor interference. Cogn Affect Behav Neurosci, 4, 517-27.
E Zarahn, GK Aguirre, M D'Esposito. (2000). Replication and further studies of neural mechanisms of spatial mnemonic processing in humans. Cognitive Brain Research, 9, 1-17.
M D'Esposito, D Ballard, E Zarahn, GK Aguirre. (2000). The Role of Prefrontal Cortex in Sensory Memory and Motor Preparation: An Event-Related fMRI Study. NeuroImage, 11, 400-408.
E Zarahn, GK Aguirre, M D'Esposito. (1999). Temporal isolation of the neural substrates of spatial mnemonic processing with fMRI. Cognitive Brain Research, 7, 255-268.
SL Thompson-Schill, GK Aguirre, M D'Esposito, MJ Farah. (1999). A neural basis for category and modality specificity of semantic knowledge. Neuropsychologia, 37, 671-676.
M D'Esposito, D Ballard, GK Aguirre, E Zarahn. (1998). Human prefrontal cortex is not specific for working memory. NeuroImage, 8, 274-282.
M D'Esposito, GK Aguirre, E Zarahn, D Ballard, RK Shin, J Lease. (1998). Functional MRI studies of spatial and nonspatial working memory. Cogn Brain Res, 7, 1-13.
SL Thompson-Schill, M D'Esposito, GK Aguirre, MJ Farah. (1997). Role of left inferior prefrontal cortex in retrieval of semantic knowledge: a reevaluation. PNAS USA, 94, 14792-14797.
LT Zorrilla, GK Aguirre, E Zarahn, TD Cannon, M D'Esposito. (1996). Activation of the prefrontal cortex during judgments of recency: a functional MRI study. Neuroreport, 7, 2803-2806.

Clinical Neurology

DJ Libon, C McMillan, D Gunawardena, C Powers, L Massimo, A Khan, B Morgan, C Farag, L Richmond, J Weinstein, P Moore, HB Coslett, A Chatterjee, G Aguirre, M Grossman. (2009). Neurocognitive contributions to verbal fluency deficits in frontotemporal lobar degeneration. Neurology, 73(7), 535-42.
AL Thomas, K Lawler, IR Olson, GK Aguirre. (2008). The Philadelphia Face Perception Battery. Archives of Clinical Neuropsychology, 23(2), 175-187.
AM Harris, GK Aguirre. (2007). Toward a Neurofunctional Definition of “Face-Blindness”. Scientific American Mind Matters. Ed: David Dobbs.
AM Harris, GK Aguirre. (2007). Prosopagnosia. Current Biology, 17, 7-8.
DJ Libon, L Massimo, P Moore, HB Coslett, A Chatterjee, GK Aguirre, A Rice, L Vesely, M Grossman. (2007). Screening for frontotemporal dementias and Alzheimer's disease with the Philadelphia brief assessment of cognition: a preliminary analysis. Dement Geriatr Cogn Disord, 24(6), 441-447.
GK Aguirre. (2006). Interpretation of clinical functional neuroimaging studies. In: D'Esposito, M. (Ed.), Functional MRI: Applications in Clinical Neurology Parthenon Publishing, New York.
GK Aguirre, JM Ellenbogen, J Pollard, ED Stolzenberg, SL Galetta. (2002). Amyloid angiopathy. Neurology, 59, 1656.
GK Aguirre. (2002). Topographical Disorientation. In M D’Esposito (Ed.) Neurological Foundations of Cognitive Neuroscience. Boston: MIT Press.
GK Aguirre, M D'Esposito. (1999). Topographical disorientation: a synthesis and taxonomy. Brain, 122, 1613-1628.
M D'Esposito, E Zarahn, GK Aguirre, B Rypma. (1999). The effect of normal aging on coupling of neural activity to the BOLD hemodynamic response. NeuroImage, 10, 6-14.
JA Detre, L Maccotta, D King, DC Alsop, G Glosser, M D'Esposito, E Zarahn, GK Aguirre, JA French. (1998). Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology, 50, 926-932.
JA Detre, DC Alsop, GK Aguirre, MR Sperling. (1996). Coupling of cortical and thalamic ictal activity in human partial epilepsy: demonstration by functional magnetic resonance imaging. Epilepsia, 37, 657-661.

Other

GK Stefanatos, WQ Joe, GK Aguirre, JA Detre, G Wetmore. (2007). Activation of human auditory cortex during speech perception: Effects of monaural, binaural, and dichotic presentation. Neuropsychologia, 46(1), 301-315.
SM Schaefer, DC Jackson, RJ Davidson, GK Aguirre, DY Kimberg, SL Thompson-Schill. (2002). Modulation of amygdala activity by conscious maintenance of negative emotion. Journal of Cognitive Neuroscience, 14, 913-921.
DY Kimberg, GK Aguirre, J Lease, M D'Esposito. (2001). Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI. Human Brain Mapping, 12, 246-257.
DY Kimberg, GK Aguirre, M D'Esposito. (2000). Modulation of task-related neural activity in task-switching: an fMRI study. Cognitive Brain Research, 10, 189-196.