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Lab Publications by Topic

Face and Object Perception

DA Kahn, GK Aguirre. Confounding of norm-based and adaptation effects in brain responses. Neuroimage
DA Kahn, AM Harris, DA Wolk, GK Aguirre. (2010) Temporally distinct neural coding of perceptual similarity and prototype bias. Journal of Vision, 10(10):12, 1-12.
[ Stimulus details page ]
A Harris, GK Aguirre. (2010) Neural Tuning for Face Wholes and Parts in Human Fusiform Gyrus Revealed by fMRI Adaptation. Journal of Neurophysiology. 104(1):336-45..
[ Behavioral data for experiment 3 ]
DM Drucker, WT Kerr, GK Aguirre. (2009) Distinguishing conjoint and independent neural tuning for stimulus features with fMRI adaptation. Journal of Neurophysiology. June;101(6):3310-24
[ Link to supplementary materials ]
[ Link to Faculty of 1000 evaluation ]
[ Cached version of F1000 review ]
[ Example data set ]
DM Drucker, GK Aguirre. (2009) Different spatial scales of shape similarity representation in lateral and ventral LOC. Cerebral Cortex, 19(10), 2269-2280.
A Chatterjee, A Thomas, S Smith, GK Aguirre. (2009) The Neural Response to Facial Beauty. Neuropsychology. 23(2), 135-43.
[ Download stimuli and attractiveness ratings ]
A Harris, GK Aguirre. (2008) The Effects of Parts, Wholes, and Familiarity on Face-Selective Responses in MEG. Journal of Vision, 8(10), 1-12.
AL Thomas, K Lawler, IR Olson, GK Aguirre. (2008) The Philadelphia Face Perception Battery. Archives of Clinical Neuropsychology, 23(2), 175-187.
[ Download stimuli and administration instructions ]
A Harris, GK Aguirre. (2008) The Representation of Parts and Wholes in Face-Selective Cortex. Journal of Cognitive Neuroscience, 20(5), 863-78.
AM Harris, GK Aguirre. (2007) Toward a Neurofunctional Definition of “Face-Blindness”. Scientific American Mind Matters. Ed: David Dobbs.
AM Harris, GK Aguirre. (2007) Prosopagnosia. Current Biology, 17, 7-8.
GK Aguirre (2007) Continuous carry-over designs for fMRI. Neuroimage, 35, 1480-1494.
RA Epstein, JS Higgins, W Parker, GK Aguirre, S Cooperman (2006) Cortical correlates of face and scene inversion: a comparison. Neuropsychologia, 44, 1145-58.
TA Polk, M Stallcup, GK Aguirre, DC Alsop, M D'Esposito, JA Detre,MJ Farah. (2002) Neural specialization for letter recognition. Journal of Cognitive Neuroscience, 14, 145-159.
GK Aguirre. (2001) Turning the dial on object perception. Neuron, 29, 317-319.
GK Aguirre, R Singh, M D'Esposito. (1999) Stimulus inversion and the responses of face and object-sensitive cortical areas. Neuroreport, 10, 189-194.
MJ Farah, GK Aguirre. (1999) Imaging visual recognition: PET and fMRI studies of the functional anatomy of human visual recognition. Trends in Cognitive Sciences, 3, 179-186.
GK Aguirre. (1999) Face recognition turned upside-down. Neuron, 22, 5-6.
GK Aguirre, MJ Farah. (1998) Human visual object recognition: what have we learned from neuroimaging? Psychobiology, 26, 322-332.
GK Aguirre, E Zarahn, M D'Esposito. (1998) An area within human ventral cortex sensitive to "building" stimuli: evidence and implications. Neuron, 21, 373-383.
M D'Esposito, JA Detre, GK Aguirre, M Stallcup, DC Alsop, LJ Tippet, MJ Farah. (1997) A functional MRI study of mental image generation. Neuropsychologia, 35, 725-730.

Blindness and Recovery of Visual Function

PD Radoeva, S Prasad, DH Brainard, GK Aguirre. (2008). Neural activity within area V1 reflects unconscious visual performance in a case of Blindsight. Journal of Cognitive Neuroscience, 20(11), 1927-1939.
GK Aguirre, MA Komáromy, AV Cideciyan, DH Brainard, TS Aleman, AJ Roman, BB Avants, JC Gee, M Korczykowski, WW Hauswirth, GM Acland, GD Aguirre, SG Jacobson. (2007, Jun). Visual Cortex Intact and Responsive Despite Early Retinal Blindness from RPE65 Mutation. PLOS-Medicine, 4(6), e230.
[ A Nature Education description of the study. ]
AV Cideciyan, TS Aleman, SG Jacobson, H Khanna, A Sumaroka, GK Aguirre, SB Schwartz, EA Windsor, S He, B Chang, EM Stone, A Swaroop. (2007, Nov). Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis. Hum Mutat, 28(11), 1074-83.
TS Aleman, AV Cideciyan, GK Aguirre, WC Huang, CL Mullins, AJ Roman, A Sumaroka, MB Olivares , FF Tsai , SB Schwartz , LH Vandenberghe, MP Limberis, EM Stone, P Bell, JM Wilson, SG Jacobson (In Press) Human CRB1-associated retinal degeneration: comparison with the rd8 CRB1-mutant mouse model. Investigative Ophthalmology and Visual Science.

Functional MRI Methodology and Interpretation

GK Aguirre, MG Mattar, L Magis-Weinberg. (2011) de Bruijn cycles for neural decoding. NeuroImage 56: 1293-1300
[ Press Release ]
[ Simons Foundation "Toolbox" summary ]
L Yan, Y Zhou, Y Ye, SX Xie, J An, GK Aguirre, J Wang (2009). Physiological origin of low-frequency drift in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Magnetic Resonance in Medicine. Apr;61(4):819-27.
DM Drucker, WT Kerr, GK Aguirre. (2009). Distinguishing conjoint and independent neural tuning for stimulus features with fMRI adaptation. Journal of Neurophysiology. June;101(6):3310-24 [ Link to supplementary materials ] [ Link to Faculty of 1000 evaluation ]
GK Aguirre. (2008, Sept 12). The Political Brain. Cerebrum.
M Bedny, GK Aguirre, SL Thompson-Schill. (2007) Item analysis in functional magnetic resonance imaging. Neuroimage, 35, 1093-1102.
GK Aguirre (2007) Continuous carry-over designs for fMRI. Neuroimage, 35, 1480-1494.
GK Aguirre. (2006). Interpretation of clinical functional neuroimaging studies. In: D'Esposito, M. (Ed.), Functional MRI: Applications in Clinical Neurology Parthenon Publishing, New York.
GK Aguirre. (2006). Experimental Design and Data Analysis for fMRI. In F. Mohamed & S. H. Faro (Eds.), Functional MRI:Basic Principles and Clinical Applications. Springer-Verlag, New York.
J Wang, Z Wang, GK Aguirre, JA Detre. (2005). To smooth or not to smooth? ROC analysis of perfusion fMRI data. Magn Reson Imaging, 23, 75-81.
GK Aguirre. (2003). Functional imaging in behavioral neurology and cognitive neuropsychology. In T. E. Feinberg & M. J. Farah (Eds.), Behavioral Neurology and Cognitive Neuropsychology. New York: McGraw Hill.
GK Aguirre, JA Detre, E Zarahn, D C Alsop. (2002). Experimental design and the relative sensitivity of BOLD and perfusion fMRI. NeuroImage, 15, 488-500.
GK Aguirre, M D'Esposito. (1999). Experimental Design for Brain fMRI. In C. T. W. Moonen & P. A. Bandettini (Eds.), Functional MRI (pp. 369-380). Berlin: Springer Verlag.
M D'Esposito, E Zarahn, GK Aguirre. (1999). Event-related functional MRI: Implications for cognitive psychology. Psychological Bulletin, 125.
M D'Esposito, E Zarahn, GK Aguirre, B Rypma. (1999). The effect of normal aging on coupling of neural activity to the BOLD hemodynamic response. NeuroImage, 10, 6-14.
GK Aguirre, E Zarahn, M D'Esposito. (1998). A critique of the use of the Kolmogorov-Smirnov (KS) statistic for the analysis of BOLD fMRI data. Magnetic Resonance in Medicine, 39, 500-505.
GK Aguirre, E Zarahn, M D'Esposito. (1998). The inferential impact of global signal covariates in functional neuroimaging analyses. NeuroImage, 8, 302-306.
GK Aguirre, E Zarahn, M D'Esposito. (1998). The variability of human BOLD hemodynamic responses. NeuroImage, 8, 360-369.
E Zarahn, GK Aguirre, M D'Esposito. (1997). A trial-based experimental design for fMRI. Neuroimage, 6, 122-138.
M D'Esposito, E Zarahn, GK Aguirre, RK Shin, P Auerbach, JA Detre. (1997). The effect of pacing of experimental stimuli on observed functional MRI activity. Neuroimage, 6, 113-121.
E Zarahn, GK Aguirre, M D'Esposito. (1997). Empirical analyses of BOLD fMRI statistics. I. Spatially unsmoothed data collected under null-hypothesis conditions. Neuroimage, 5, 179-197.
GK Aguirre, E Zarahn, M D'Esposito. (1997). Empirical analyses of BOLD fMRI statistics. II. Spatially smoothed data collected under null-hypothesis and experimental conditions. Neuroimage, 5, 199-212.

Perfusion fMRI

Z Wang, GK Aguirre, H Rao, J Wang, MA Fernández-Seara, AR Childress, JA Detre. (2007). Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx. Magn Reson Imaging, 26(2), 261-269.
I Olson, H Rao, K Sledge Moore, J Wang, J Detre, GK Aguirre (2006). Using Perfusion fMRI to Measure Continuous Changes in Neural Activity with Learning. Brain and Cognition, 60, 262-71.
GK Aguirre, JA Detre, J Wang. (2005). Perfusion fMRI for functional neuroimaging. Int Rev Neurobiol, 66, 213-36. Download pdf preprint
J Wang, GK Aguirre, DY Kimberg, JA Detre. (2003). Empirical Analyses of Null-Hypothesis Perfusion fMRI Data at 1.5 and 4T. NeuroImage, 19, 1449-62.
J Wang, GK Aguirre, DY Kimberg, AC Roc, L Li, JA Detre. (2003). Arterial Spin Labeling Perfusion fMRI with Very Low Task Frequency. Magn Reson Med, 49, 796-802.
GK Aguirre, JA Detre, E Zarahn, D C Alsop. (2002). Experimental design and the relative sensitivity of BOLD and perfusion fMRI. NeuroImage, 15, 488-500.

Topographical Orientation

LK Morgan, SP MacEvoy, GK Aguirre, and RA Epstein. (2011). Distances between real-world locations are represented in the human hippocampus. Journal of Neuroscience. 31(4):1238-1245
GK Aguirre. (2002). Topographical Disorientation. In M D’Esposito (Ed.) Neurological Foundations of Cognitive Neuroscience. Boston: MIT Press.
GK Aguirre, M D'Esposito. (1999). Topographical disorientation: a synthesis and taxonomy. Brain, 122, 1613-1628.
GK Aguirre, E Zarahn, M D'Esposito. (1998). An area within human ventral cortex sensitive to "building" stimuli: evidence and implications. Neuron, 21, 373-383.
GK Aguirre, M D'Esposito. (1997). Environmental knowledge is subserved by separable dorsal/ventral neural areas. Journal of Neuroscience, 17, 2512-2518.
GK Aguirre, JA Detre, DC Alsop, M D'Esposito. (1996). The parahippocampus subserves topographical learning in man. Cerebral Cortex, 6, 823-829.
[ View PDF with Color Figures ]
GK Aguirre, E Zarahn, M D'Esposito. (1998). Neural components of topographical representation. PNAS USA, 95, 839-846.

Learning and Memory

I Olson, H Rao, K Sledge Moore, J Wang, J Detre, GK Aguirre (2006). Using Perfusion fMRI to Measure Continuous Changes in Neural Activity with Learning. Brain and Cognition, 60, 262-71.
AP Jha, SA Fabian, GK Aguirre. (2004). The role of prefrontal cortex in resolving distractor interference. Cogn Affect Behav Neurosci, 4, 517-27.
E Zarahn, GK Aguirre, M D'Esposito. (2000). Replication and further studies of neural mechanisms of spatial mnemonic processing in humans. Cognitive Brain Research, 9, 1-17.
M D'Esposito, D Ballard, E Zarahn, GK Aguirre. (2000). The Role of Prefrontal Cortex in Sensory Memory and Motor Preparation: An Event-Related fMRI Study. NeuroImage, 11, 400-408.
E Zarahn, GK Aguirre, M D'Esposito. (1999). Temporal isolation of the neural substrates of spatial mnemonic processing with fMRI. Cognitive Brain Research, 7, 255-268.
SL Thompson-Schill, GK Aguirre, M D'Esposito, MJ Farah. (1999). A neural basis for category and modality specificity of semantic knowledge. Neuropsychologia, 37, 671-676.
M D'Esposito, D Ballard, GK Aguirre, E Zarahn. (1998). Human prefrontal cortex is not specific for working memory. NeuroImage, 8, 274-282.
M D'Esposito, GK Aguirre, E Zarahn, D Ballard, RK Shin, J Lease. (1998). Functional MRI studies of spatial and nonspatial working memory. Cogn Brain Res, 7, 1-13.
SL Thompson-Schill, M D'Esposito, GK Aguirre, MJ Farah. (1997). Role of left inferior prefrontal cortex in retrieval of semantic knowledge: a reevaluation. PNAS USA, 94, 14792-14797.
LT Zorrilla, GK Aguirre, E Zarahn, TD Cannon, M D'Esposito. (1996). Activation of the prefrontal cortex during judgments of recency: a functional MRI study. Neuroreport, 7, 2803-2806.

Clinical Neurology

R Datta, JA Detre, GK Aguirre, B Cucchiara. (2011). Absence of grey matter changes in patients with migraine. Cephalalgia. 14:1452-8
AK Asbury, MR Sperling, GK Aguirre, GT Liu. (2010). Selected contributions to Neurology by Philadelphia neurologists since 1980 (prepared in association with the 125th anniversary celebration meeting of the Philadelphia Neurological Society on Feb. 20, 2008). Reviews in Neurological Diseases 7(4):140-9.
DJ Libon, C McMillan, D Gunawardena, C Powers, L Massimo, A Khan, B Morgan, C Farag, L Richmond, J Weinstein, P Moore, HB Coslett, A Chatterjee, G Aguirre, M Grossman. (2009). Neurocognitive contributions to verbal fluency deficits in frontotemporal lobar degeneration. Neurology, 73(7), 535-42.
AL Thomas, K Lawler, IR Olson, GK Aguirre. (2008). The Philadelphia Face Perception Battery. Archives of Clinical Neuropsychology, 23(2), 175-187.
AM Harris, GK Aguirre. (2007). Toward a Neurofunctional Definition of “Face-Blindness”. Scientific American Mind Matters. Ed: David Dobbs.
AM Harris, GK Aguirre. (2007). Prosopagnosia. Current Biology, 17, 7-8.
DJ Libon, L Massimo, P Moore, HB Coslett, A Chatterjee, GK Aguirre, A Rice, L Vesely, M Grossman. (2007). Screening for frontotemporal dementias and Alzheimer's disease with the Philadelphia brief assessment of cognition: a preliminary analysis. Dement Geriatr Cogn Disord, 24(6), 441-447.
GK Aguirre. (2006). Interpretation of clinical functional neuroimaging studies. In: D'Esposito, M. (Ed.), Functional MRI: Applications in Clinical Neurology Parthenon Publishing, New York.
GK Aguirre, JM Ellenbogen, J Pollard, ED Stolzenberg, SL Galetta. (2002). Amyloid angiopathy. Neurology, 59, 1656.
GK Aguirre. (2002). Topographical Disorientation. In M D’Esposito (Ed.) Neurological Foundations of Cognitive Neuroscience. Boston: MIT Press.
GK Aguirre, M D'Esposito. (1999). Topographical disorientation: a synthesis and taxonomy. Brain, 122, 1613-1628.
M D'Esposito, E Zarahn, GK Aguirre, B Rypma. (1999). The effect of normal aging on coupling of neural activity to the BOLD hemodynamic response. NeuroImage, 10, 6-14.
JA Detre, L Maccotta, D King, DC Alsop, G Glosser, M D'Esposito, E Zarahn, GK Aguirre, JA French. (1998). Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology, 50, 926-932.
JA Detre, DC Alsop, GK Aguirre, MR Sperling. (1996). Coupling of cortical and thalamic ictal activity in human partial epilepsy: demonstration by functional magnetic resonance imaging. Epilepsia, 37, 657-661.

Other

GK Aguirre. FIASCO, VoxBo, and MEDx: Behind the code. Neuroimage
EB Wencil, GK Aguirre, HB Coslett, A Chatterjee. (2010). Carving the clock at its component joints: Neural basis for interval timing. J Neurophysiology. 104: 160-168.
GK Stefanatos, WQ Joe, GK Aguirre, JA Detre, G Wetmore. (2007). Activation of human auditory cortex during speech perception: Effects of monaural, binaural, and dichotic presentation. Neuropsychologia, 46(1), 301-315.
SM Schaefer, DC Jackson, RJ Davidson, GK Aguirre, DY Kimberg, SL Thompson-Schill. (2002). Modulation of amygdala activity by conscious maintenance of negative emotion. Journal of Cognitive Neuroscience, 14, 913-921.
DY Kimberg, GK Aguirre, J Lease, M D'Esposito. (2001). Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI. Human Brain Mapping, 12, 246-257.
DY Kimberg, GK Aguirre, M D'Esposito. (2000). Modulation of task-related neural activity in task-switching: an fMRI study. Cognitive Brain Research, 10, 189-196.